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In a recent study, we described the identification as well as the characterization of a brand new atypical opioid receptor with exceptional detrimental regulatory Qualities in direction of opioid peptides.1 Our final results confirmed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can also be a